49ers’ Week 15: Who replaces two starters vs Titans?

December 13, 2025

49ers rule out two defensive starters for Week 15 vs. Titans

Quick take

49ers rule out two defensive starters for Week 15 vs. Titans, a late setback that forces immediate lineup shuffles and raises questions about San Francisco’s defensive identity. The starters lost are Tatum Bethune and Sam Okuayinonu. Both are out with high ankle sprains, and their absence removes key run fit and edge depth. As a result, the 49ers must pivot to younger rotation pieces and short term starters.

Why it matters

Bethune ranks among the team leaders in tackles this season, so his loss affects tackling and zone discipline. Okuayinonu started many early games and brings interior rush ability, so the pass rush will lose proven snaps. Moreover, Nick Martin remains in the concussion protocol, which further complicates game day depth. Curtis Robinson now projects to start in Bethune’s place, while Eric Kendricks is not available because of a calf strain.

What to watch

Watch how coach Kyle Shanahan mixes defensive linemen and linebackers. Also watch whether the team fires up rotation players like Yetur Gross Matos or Kurtis Rourke. Finally, expect increased snaps for backups and a heavier emphasis on assignment football.

Two simplified defensive player silhouettes with red medical crosses near their ankle areas to indicate high-ankle sprains. Neutral stadium background and San Francisco color accents on helmets. No text in image.

49ers rule out two defensive starters for Week 15 vs. Titans

The 49ers rule out two defensive starters for Week 15 vs. Titans, as Tatum Bethune and Sam Okuayinonu are sidelined with high-ankle sprains. This update lands early and changes the defensive picture immediately. For confirmation, see the team injury report and coverage from 49ers communications and NBC Sports Bay Area. 49ers Injury Report NBC Sports Coverage

Key injury details and season stats

  • Tatum Bethune — High-ankle sprain; tied for second on the team with 64 tackles this season. He provides reliable run defense and consistent tackling. Therefore, his absence removes a central run-stopping piece.
  • Sam Okuayinonu — High-ankle sprain; two sacks and steady rotational snaps through the first part of the season. His loss reduces interior edge pressure and veteran depth.

Expected impact and depth moves

Curtis Robinson is expected to make his third start in Bethune’s spot, so look for him to carry more run-fit responsibilities. Also, Nick Martin remains in the concussion protocol, which further strains depth on game day. As a result, the 49ers will lean on rotation players and assignment discipline. Coaches may open practice windows for Yetur Gross-Matos or Kurtis Rourke, but neither projects to be active. Ultimately, these injuries force a more conservative front and more situational substitutions.

Quick comparison: Injured starters and replacements

Player NamePositionGames StartedKey StatsInjury Status or Replacement Note
Tatum BethuneLinebackerStarter (multiple)64 tackles (tied for team second)Out with high-ankle sprain — will miss Week 15
Sam OkuayinonuEdge/Defensive lineman9 of first 12 games2 sacks this seasonOut with high-ankle sprain — reduces interior edge depth
Curtis RobinsonLinebacker2 (projected 3rd start)Rotational defender, special teams contributorExpected to start in Bethune’s spot for Week 15
Rotational defensive linemen (Bryce Huff, Keion White, others)Defensive end / Line rotationMultiple (rotated)Team rotated eight linemen in Week 13Team will rely on rotation to cover Okuayinonu’s snaps; no single officially named replacement

Note: The 49ers also opened practice windows for Yetur Gross-Matos and Kurtis Rourke but did not activate them. Eric Kendricks is on the practice squad with a grade 1 calf strain and is not eligible to be elevated for this game.

Tennessee Titans Week 15 Injuries

The Tennessee Titans enter Week 15 with several notable absences and question marks. Their injury list could alter offensive line continuity and secondary depth. Therefore, the matchup with the 49ers may look different than expected. The original report with these notes appeared alongside the 49ers update on NBC Sports Bay Area and team releases. Source

Key Titans injury notes

  • Jalyn Armour-Davis — Out with an Achilles injury; this removes a cornerback option and limits depth in the slot.
  • Lloyd Cushenberry III — Questionable with a foot issue; his availability affects interior offensive line stability.
  • Dan Moore Jr. — Questionable with a neck concern; if limited, the Titans could shift protections and tackle matchups.
  • C.J. Ravenell — Out with a toe injury; depth at running back and return duties could shift.
  • James Williams — Marked as ill; availability is unclear and may change game plans.
  • Kevin Zeitler — Listed with a groin issue; his status could force line rotations.

Comparing the injuries

Both teams face problems. The 49ers lost two defensive starters, Tatum Bethune and Sam Okuayinonu, to high-ankle sprains. Source

As a result, expect tactical adjustments from both staffs. The Titans may protect their injured linemen and test the 49ers without key run defenders. Conversely, San Francisco will lean on rotation and assignment discipline to compensate.

CONCLUSION

The San Francisco 49ers ruled out two defensive starters for Week 15 vs. Titans, Tatum Bethune and Sam Okuayinonu, both sidelined by high-ankle sprains. Their absences force lineup shifts, increased snaps for Curtis Robinson, and heavier rotation along the defensive front. Because Bethune ranks high in tackles and Okuayinonu supplied interior pass rush, the 49ers lose key run defense and edge depth. Nick Martin remaining in concussion protocol adds further strain to depth charts.

The Titans also carry injuries, so both staffs will adjust game plans and protections. For ongoing updates and roster moves, see Rams News LLC and follow reporter @ZachGatsby for rapid posts. Expect coach Kyle Shanahan to emphasize assignment football and situational substitutions to limit exposure.

Frequently Asked Questions (FAQs)

Which 49ers players are ruled out for Week 15?

Tatum Bethune and Sam Okuayinonu are ruled out with high-ankle sprains. Also, both will miss the game.

Who will replace them in the lineup?

Curtis Robinson is expected to start in Bethune’s spot. For Okuayinonu the team will rotate defensive linemen. As a result, Bryce Huff and Keion White could see expanded snaps.

How will these absences affect San Francisco’s defense?

The 49ers lose a top tackler and interior edge depth. Therefore, the team will rely on assignment discipline and rotation. Coaches may call safer fronts against the run.

Can Eric Kendricks or Yetur Gross-Matos be elevated?

Eric Kendricks has a grade 1 calf strain and is not available to elevate. The team opened practice windows for Yetur Gross-Matos and Kurtis Rourke. However, neither will be active for Week 15.

What should fans and fantasy managers watch for?

Monitor snap counts and pregame injury reports. Also watch for heavier rotation and changed matchup notes. These clues will show how the 49ers adapt.